CLOVERS study examines ways of increasing blood pressure in sepsis patients

UC Health News

Sepsis occurs when the body has a severe reaction to
infection, that can become a life-threatening condition, and one of the major
dangers for sepsis patients is low blood pressure. Researchers at the
University of Cincinnati (UC) are involved in a national study comparing two
methods of increasing blood pressure in those patients. The study could
determine which treatment is more effective and as a result reduce the high
mortality rates in sepsis patients.

Over 1.5 million people in the United States and 19 million
worldwide get sepsis every year, according to Kristin Hudock, MD, assistant
professor in the Division of Pulmonary, Critical Care and Sleep Medicine in the
Department of Internal Medicine at the UC College of Medicine, and the UC site
principal investigator on the study.

“We’re looking specifically at septic shock which is a more
extreme version of sepsis,” says Hudock. “Depending on the source of the
information, there is anywhere from 25 percent to 40 percent mortality in that
patient population. It affects all kinds of people—seemingly healthy people,
transplant patients, patients with malignancies or other immune-compromised
states.”

The Crystalloid Liberal or Vasopressors Early Resuscitation
in Sepsis (CLOVERS) study compares two standards of care for increasing blood
pressure in patients with dangerously low blood pressure due to a suspected
infection. One method is to first provide intravenous fluids to the patient,
and then use drugs such as adrenalin (called vasopressors). The other method is
to use the drugs first, and then use fluids.

The multi-center, prospective phase 3 randomized non-blinded
interventional trial will enroll up to 2,230 subjects over three years from the
Clinical Trials Network for the Prevention and Early Treatment of Acute Lung
Injury (PETAL) network emergency departments including UC Medical Center. PETAL
is a network of 12 clinical centers and one clinical coordinating center funded
by the National Heart, Lung and Blood Institute. Approximately 50 hospitals,
including Johns Hopkins, …

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